منابع مشابه
Genetic code ambiguity confers a selective advantage on Acinetobacter baylyi.
A primitive genetic code, composed of a smaller set of amino acids, may have expanded via recursive periods of genetic code ambiguity that were followed by specificity. Here we model a step in this process by showing how genetic code ambiguity could result in an enhanced growth rate in Acinetobacter baylyi.
متن کاملMutational unmasking of a tRNA-dependent pathway for preventing genetic code ambiguity.
Aminoacyl-tRNA synthetases establish the genetic code by matching each amino acid with its cognate tRNA. Aminoacylation errors lead to genetic code ambiguity and statistical proteins. Some synthetases have editing activities that clear the wrong amino acid (aa) by hydrolysis of either of two substrates: misactivated aminoacyl-adenylates ("pretransfer" of aa to tRNA) or misacylated aa-tRNA ("pos...
متن کاملAnalysis of Genetic Code Ambiguity Arising from Nematode-Specific Misacylated tRNAs
The faithful translation of the genetic code requires the highly accurate aminoacylation of transfer RNAs (tRNAs). However, it has been shown that nematode-specific V-arm-containing tRNAs (nev-tRNAs) are misacylated with leucine in vitro in a manner that transgresses the genetic code. nev-tRNA(Gly) (CCC) and nev-tRNA(Ile) (UAU), which are the major nev-tRNA isotypes, could theoretically decode ...
متن کاملGenetic code ambiguity: an unexpected source of proteome innovation and phenotypic diversity.
Translation of the genome into the proteome is a highly accurate biological process. However, the molecular mechanisms involved in protein synthesis are not error free and downstream protein quality control systems are needed to counteract the negative effects of translational errors (mistranslation) on proteome and cell homeostasis. This plus human and mice diseases caused by translational err...
متن کاملGenetic code
Is the code universal? No. Although most organisms have the same genetic code, researchers began to discover exceptions to the ‘universal’ code in 1979, and today we know of more than 15 alternative codes; each has just a few differences from the standard code, indicating common ancestry from this code. Several of these codes arose independently a number of times in evolution and are present in...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2002
ISSN: 0021-9258
DOI: 10.1074/jbc.m208093200